The best way to deal with coronary artery plaque, or blockage, is to prevent it from forming in the first place. Not smoking or quitting smoking has the most impact, but eating a balanced diet low in carbohydrates and saturated fats, regularly exercising (150 minutes or more per week spread out over 4-5 days), and getting enough sleep can also help.
Coronary plaque CAN BE REDUCED by following the above guidelines while also taking enough of a statin drug to reduce blood cholesterol levels by at least 50%. In such patients, coronary plaque has been shown to decrease by up to 10%.